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Zyprexa linked with Diabetes, Judge scales back Lawsuit. PDF Print E-mail
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Written by Toma Grubb   
Friday, 25 April 2008
Arlene, A new member to our site alerted me to a new drug warning. I started doing a little digging and found some disturbing results. Not only is there a problem, but the FDA and the legal system are working to sweep it under the carpet. Thank you Arlene.

For some time we have been aware of higher risks of type 2 diabetes in people with depression. When I first heard of it was unclear if diabetes was causing the depression or if depression increased the risks. Now the picture is a bit clearer.

Zyprexa linked with Diabetes

Eli Lilly's best selling drug, olanzapine (Zyprexa), originally approved for schizophrenia, then for bi-polar disorder, is prescribed widely. But the drug has been shown to produce early onset diabetes, severe hyperglycemia--and deaths. Adolescents and young adults appear to be at particular risk.

On November 28, 2001, the Journal of the American Medical Association published a letter written by Dr. Elizabeth Koller, an FDA medical officer, Dr. P. Murali Doraiswamy, a Duke University psychiatrist warning that according to FDA's MedWatch data, patients taking either olanzapine or clozapine were 10 times more likely to become diabetic than the general population.

JAMA

Those findings have been corroborated by several other studies. Yet, the FDA has done little to warn doctors and consumers. Patients taking the drug should, at the very least have their blood sugar monitored, but if doctors are unaware of the risk patients are not monitored.


The Baltimore Sun reports:

"Japan's Health Ministry, concerned by reports of two deaths and seven comas, barred doctors last year from prescribing Zyprexa for any new patients with diabetes, and warned them to monitor closely those already on the drug by regularly measuring blood-sugar levels. British drug regulators issued a warning in April."

According to Dr. Doaiswamy, in Japan, a strong, highlighted warning appears at the very beginning of the Zyprexa label. The FDA has not required a warning beyond inconspicuous mention of the possibility of sugar problems in patients who take atypicals.

Public Citizen advises physicians and consumers to look to the Japanese label for the most accurate information. It states:

* Olanzapine is contra-indicated for use in patients with diabetes or a history of diabetes.

* Olanzapine should be used with caution in patients with risk factors for diabetes, including hyperglycemia, obesity or a family history of diabetes.

* Patients receiving olanzapine should be carefully monitored for symptoms of hyperglycemia and the drug should be discontinued if such symptoms occur. The symptoms of severe hyperglycemia include weakness, excessive eating, excessive thirst, and excessive urination.

* Physicians should educate patients and their family members about the risk of serious hyperglycemia associated with the olanzapine and how to identify the symptoms of hyperglycemia.


Now the story takes a new twist; Zyprexa Lawsuit to be scaled back per Judge

POSTED: Wednesday, April 16, 2008

FROM BLOG: Injury Law Blog - legal blog covering injury law issues

The following blog post is from an independent writer and is not connected with Reuters News. The opinions and views expressed herein are those of the author and are not endorsed by Reuters.com.

In a widely discussed article on Bloomberg.com, Judge Jack Weinstein, an outspoken U.S. District Judge  from New York, has stated that he does not want to allow patients and insurers who paid for Zyprexa for uses approved by the U.S. Food and Drug Administration, including schizophrenia and bipolar disorder, to sue as a group. Further he does not feel that the purchasers of the Zyprexa drug are entitled to  claim punitive damages. The case ``ought to be settled,'' said the judge to both Plaintiff and Defense lawyers. "I really think that we're not dealing with very much money.''

See full story here


It is very obvious that the FDA is not doing its job to protect us. One has to wonder if the judge is taking a kickback from Eli Lilly.  Type 2 diabetes is best controlled with diet yet mainstream medicine is still pushing drugs as their preferred method of trying to treat  the ever increasing epidemic.  The FDA is not doing its job and allowing the pharmaceuticals to push more and more drugs that are causing harm.

 

 
 
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